/* ================================================
   DNA ANALYSIS - Modern Dark Theme
   ================================================ */

:root {
    /* Color Palette - Bioluminescent Theme */
    --bg-primary: #0a0e17;
    --bg-secondary: #111827;
    --bg-card: #1a2235;
    --bg-card-hover: #232d42;
    
    /* Accent Colors */
    --accent-cyan: #06d6a0;
    --accent-cyan-glow: rgba(6, 214, 160, 0.3);
    --accent-purple: #8b5cf6;
    --accent-purple-glow: rgba(139, 92, 246, 0.3);
    --accent-pink: #ec4899;
    --accent-blue: #3b82f6;
    --accent-amber: #f59e0b;
    --accent-red: #ef4444;
    --accent-green: #22c55e;
    
    /* Text Colors */
    --text-primary: #f1f5f9;
    --text-secondary: #94a3b8;
    --text-muted: #64748b;
    
    /* Nucleotide Colors */
    --color-adenine: #ef4444;
    --color-thymine: #3b82f6;
    --color-cytosine: #22c55e;
    --color-guanine: #f59e0b;
    
    /* Borders & Shadows */
    --border-color: rgba(148, 163, 184, 0.1);
    --shadow-lg: 0 25px 50px -12px rgba(0, 0, 0, 0.5);
    --shadow-glow: 0 0 40px var(--accent-cyan-glow);
    
    /* Spacing */
    --container-max: 1200px;
    --spacing-xs: 0.25rem;
    --spacing-sm: 0.5rem;
    --spacing-md: 1rem;
    --spacing-lg: 1.5rem;
    --spacing-xl: 2rem;
    --spacing-2xl: 3rem;
    
    /* Border Radius */
    --radius-sm: 0.375rem;
    --radius-md: 0.75rem;
    --radius-lg: 1rem;
    --radius-xl: 1.5rem;
    
    /* Transitions */
    --transition-fast: 150ms ease;
    --transition-base: 250ms ease;
    --transition-slow: 400ms ease;
}

/* ================================================
   Reset & Base Styles
   ================================================ */

*, *::before, *::after {
    box-sizing: border-box;
    margin: 0;
    padding: 0;
}

html {
    font-size: 16px;
    scroll-behavior: smooth;
}

body {
    font-family: 'Outfit', -apple-system, BlinkMacSystemFont, sans-serif;
    background: var(--bg-primary);
    color: var(--text-primary);
    line-height: 1.6;
    min-height: 100vh;
    overflow-x: hidden;
}

/* ================================================
   DNA Background Animation
   ================================================ */

.dna-background {
    position: fixed;
    top: 0;
    left: 0;
    right: 0;
    bottom: 0;
    pointer-events: none;
    overflow: hidden;
    z-index: 0;
}

.helix-strand {
    position: absolute;
    width: 100%;
    height: 200%;
    background: 
        radial-gradient(ellipse 2px 8px at 20% 0%, var(--accent-cyan) 0%, transparent 100%),
        radial-gradient(ellipse 2px 8px at 80% 10%, var(--accent-purple) 0%, transparent 100%),
        radial-gradient(ellipse 2px 8px at 30% 20%, var(--accent-cyan) 0%, transparent 100%),
        radial-gradient(ellipse 2px 8px at 70% 30%, var(--accent-purple) 0%, transparent 100%),
        radial-gradient(ellipse 2px 8px at 25% 40%, var(--accent-cyan) 0%, transparent 100%),
        radial-gradient(ellipse 2px 8px at 75% 50%, var(--accent-purple) 0%, transparent 100%),
        radial-gradient(ellipse 2px 8px at 35% 60%, var(--accent-cyan) 0%, transparent 100%),
        radial-gradient(ellipse 2px 8px at 65% 70%, var(--accent-purple) 0%, transparent 100%),
        radial-gradient(ellipse 2px 8px at 20% 80%, var(--accent-cyan) 0%, transparent 100%),
        radial-gradient(ellipse 2px 8px at 80% 90%, var(--accent-purple) 0%, transparent 100%);
    background-size: 100% 50%;
    opacity: 0.15;
    animation: helix-float 20s ease-in-out infinite;
}

.strand-2 {
    animation-delay: -10s;
    animation-direction: reverse;
}

@keyframes helix-float {
    0%, 100% { transform: translateY(0) rotate(0deg); }
    50% { transform: translateY(-25%) rotate(5deg); }
}

/* Gradient Overlay */
.dna-background::after {
    content: '';
    position: absolute;
    inset: 0;
    background: 
        radial-gradient(circle at 30% 20%, var(--accent-cyan-glow) 0%, transparent 50%),
        radial-gradient(circle at 70% 80%, var(--accent-purple-glow) 0%, transparent 50%);
    opacity: 0.4;
}

/* ================================================
   Container & Layout
   ================================================ */

.container {
    position: relative;
    z-index: 1;
    max-width: var(--container-max);
    margin: 0 auto;
    padding: var(--spacing-xl);
    min-height: 100vh;
    display: flex;
    flex-direction: column;
}

/* ================================================
   Header
   ================================================ */

.header {
    text-align: center;
    padding: var(--spacing-2xl) 0;
    animation: fade-in-down 0.6s ease-out;
}

.logo {
    display: flex;
    align-items: center;
    justify-content: center;
    gap: var(--spacing-md);
    margin-bottom: var(--spacing-md);
}

.dna-icon {
    width: 48px;
    height: 48px;
    color: var(--accent-cyan);
    animation: pulse-glow 2s ease-in-out infinite;
}

@keyframes pulse-glow {
    0%, 100% { filter: drop-shadow(0 0 8px var(--accent-cyan-glow)); }
    50% { filter: drop-shadow(0 0 20px var(--accent-cyan)); }
}

.logo h1 {
    font-size: 2.5rem;
    font-weight: 700;
    letter-spacing: -0.02em;
    color: var(--text-primary);
}

.logo .highlight {
    background: linear-gradient(135deg, var(--accent-cyan), var(--accent-purple));
    -webkit-background-clip: text;
    -webkit-text-fill-color: transparent;
    background-clip: text;
}

.tagline {
    font-size: 1.125rem;
    color: var(--text-secondary);
    font-weight: 300;
}

/* ================================================
   Upload Section
   ================================================ */

.upload-section {
    flex: 1;
    display: flex;
    flex-direction: column;
    align-items: center;
    justify-content: center;
    gap: var(--spacing-xl);
    animation: fade-in-up 0.6s ease-out 0.2s backwards;
}

.upload-card {
    width: 100%;
    max-width: 500px;
}

.upload-area {
    background: var(--bg-card);
    border: 2px dashed var(--border-color);
    border-radius: var(--radius-xl);
    padding: var(--spacing-2xl);
    cursor: pointer;
    transition: all var(--transition-base);
    position: relative;
    overflow: hidden;
}

.upload-area::before {
    content: '';
    position: absolute;
    inset: 0;
    background: linear-gradient(135deg, var(--accent-cyan-glow), var(--accent-purple-glow));
    opacity: 0;
    transition: opacity var(--transition-base);
}

.upload-area:hover,
.upload-area.dragover {
    border-color: var(--accent-cyan);
    transform: translateY(-2px);
    box-shadow: var(--shadow-glow);
}

.upload-area:hover::before,
.upload-area.dragover::before {
    opacity: 0.1;
}

.upload-content {
    position: relative;
    z-index: 1;
    display: flex;
    flex-direction: column;
    align-items: center;
    text-align: center;
    gap: var(--spacing-md);
}

.upload-icon {
    width: 64px;
    height: 64px;
    display: flex;
    align-items: center;
    justify-content: center;
    background: linear-gradient(135deg, var(--accent-cyan), var(--accent-purple));
    border-radius: 50%;
    margin-bottom: var(--spacing-sm);
}

.upload-icon svg {
    width: 32px;
    height: 32px;
    color: white;
}

.upload-content h3 {
    font-size: 1.25rem;
    font-weight: 600;
    color: var(--text-primary);
}

.upload-content p {
    font-size: 0.875rem;
    color: var(--text-muted);
}

.upload-btn {
    background: linear-gradient(135deg, var(--accent-cyan), var(--accent-purple));
    color: white;
    border: none;
    padding: var(--spacing-sm) var(--spacing-xl);
    border-radius: var(--radius-lg);
    font-family: inherit;
    font-size: 1rem;
    font-weight: 500;
    cursor: pointer;
    transition: all var(--transition-base);
    margin-top: var(--spacing-sm);
}

.upload-btn:hover {
    transform: scale(1.05);
    box-shadow: 0 10px 30px -10px var(--accent-cyan);
}

.demo-btn {
    background: transparent;
    color: var(--text-secondary);
    border: 1px solid var(--border-color);
    padding: var(--spacing-sm) var(--spacing-lg);
    border-radius: var(--radius-lg);
    font-family: inherit;
    font-size: 0.875rem;
    font-weight: 500;
    cursor: pointer;
    transition: all var(--transition-base);
    margin-top: var(--spacing-sm);
}

.demo-btn:hover {
    color: var(--accent-purple);
    border-color: var(--accent-purple);
    background: rgba(139, 92, 246, 0.1);
}

.file-info {
    display: flex;
    justify-content: space-between;
    padding: var(--spacing-md);
    background: var(--bg-secondary);
    border-radius: var(--radius-md);
    margin-top: var(--spacing-md);
    font-family: 'JetBrains Mono', monospace;
    font-size: 0.875rem;
}

.file-name {
    color: var(--accent-cyan);
}

.file-size {
    color: var(--text-muted);
}

/* Privacy Notice */
.privacy-notice {
    display: flex;
    align-items: center;
    gap: var(--spacing-sm);
    padding: var(--spacing-md) var(--spacing-lg);
    background: rgba(6, 214, 160, 0.1);
    border: 1px solid rgba(6, 214, 160, 0.2);
    border-radius: var(--radius-md);
    font-size: 0.875rem;
    color: var(--accent-cyan);
    max-width: 500px;
}

.privacy-notice svg {
    width: 20px;
    height: 20px;
    flex-shrink: 0;
}

/* ================================================
   Loading Section
   ================================================ */

.loading-section {
    flex: 1;
    display: flex;
    align-items: center;
    justify-content: center;
    animation: fade-in 0.4s ease-out;
}

.loading-card {
    text-align: center;
    padding: var(--spacing-2xl);
}

/* DNA Loader */
.dna-loader {
    display: flex;
    justify-content: center;
    gap: var(--spacing-md);
    margin-bottom: var(--spacing-xl);
}

.nucleotide {
    width: 16px;
    height: 16px;
    border-radius: 50%;
    animation: nucleotide-bounce 1.4s ease-in-out infinite;
}

.nucleotide.a {
    background: var(--color-adenine);
    animation-delay: 0s;
}

.nucleotide.t {
    background: var(--color-thymine);
    animation-delay: 0.2s;
}

.nucleotide.c {
    background: var(--color-cytosine);
    animation-delay: 0.4s;
}

.nucleotide.g {
    background: var(--color-guanine);
    animation-delay: 0.6s;
}

@keyframes nucleotide-bounce {
    0%, 80%, 100% {
        transform: scale(0.6);
        opacity: 0.5;
    }
    40% {
        transform: scale(1);
        opacity: 1;
    }
}

.loading-card h3 {
    font-size: 1.5rem;
    font-weight: 600;
    margin-bottom: var(--spacing-sm);
    background: linear-gradient(135deg, var(--accent-cyan), var(--accent-purple));
    -webkit-background-clip: text;
    -webkit-text-fill-color: transparent;
    background-clip: text;
}

.loading-status {
    color: var(--text-secondary);
    margin-bottom: var(--spacing-lg);
}

.progress-bar {
    width: 300px;
    height: 4px;
    background: var(--bg-card);
    border-radius: var(--radius-sm);
    overflow: hidden;
    margin: 0 auto;
}

.progress-fill {
    height: 100%;
    background: linear-gradient(90deg, var(--accent-cyan), var(--accent-purple));
    border-radius: var(--radius-sm);
    width: 0%;
    transition: width var(--transition-base);
}

/* ================================================
   Results Section
   ================================================ */

.results-section {
    animation: fade-in-up 0.6s ease-out;
}

/* Stats Overview */
/* Profile Header */
.profile-header {
    text-align: center;
    margin-bottom: var(--spacing-xl);
}

.profile-title {
    font-size: 1.75rem;
    font-weight: 600;
    background: linear-gradient(135deg, var(--accent-cyan), var(--accent-purple));
    -webkit-background-clip: text;
    -webkit-text-fill-color: transparent;
    background-clip: text;
}

/* Stats Container */
.chart-stats-container {
    margin-bottom: var(--spacing-xl);
}

.stats-overview {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(200px, 1fr));
    gap: var(--spacing-lg);
}

.stat-card {
    background: var(--bg-card);
    border: 1px solid var(--border-color);
    border-radius: var(--radius-lg);
    padding: var(--spacing-lg);
    text-align: center;
    transition: all var(--transition-base);
}

.stat-card.stat-positive {
    background: rgba(34, 197, 94, 0.1);
    border-color: rgba(34, 197, 94, 0.3);
}

.stat-card.stat-positive .stat-value {
    color: #22c55e;
}

.stat-card.stat-negative {
    background: rgba(239, 68, 68, 0.1);
    border-color: rgba(239, 68, 68, 0.3);
}

.stat-card.stat-negative .stat-value {
    color: #ef4444;
}

.stat-card.stat-neutral {
    background: rgba(100, 116, 139, 0.1);
    border-color: rgba(100, 116, 139, 0.3);
}

.stat-card.stat-neutral .stat-value {
    color: #94a3b8;
}

.stat-card:hover {
    transform: translateY(-2px);
    border-color: var(--accent-cyan);
    box-shadow: 0 0 20px var(--accent-cyan-glow);
}

.stat-value {
    display: block;
    font-size: 2rem;
    font-weight: 700;
    font-family: 'JetBrains Mono', monospace;
    background: linear-gradient(135deg, var(--accent-cyan), var(--accent-purple));
    -webkit-background-clip: text;
    -webkit-text-fill-color: transparent;
    background-clip: text;
    margin-bottom: var(--spacing-xs);
}

.stat-label {
    font-size: 0.875rem;
    color: var(--text-muted);
    text-transform: uppercase;
    letter-spacing: 0.05em;
}

/* Effect Filter Tabs */
.effect-filter-tabs {
    display: flex;
    gap: var(--spacing-sm);
    padding: var(--spacing-md);
    background: var(--bg-card);
    border-radius: var(--radius-lg);
    margin-bottom: var(--spacing-md);
    justify-content: center;
    flex-wrap: wrap;
    border: 1px solid var(--border-color);
}

.effect-btn {
    display: flex;
    align-items: center;
    gap: var(--spacing-xs);
    padding: var(--spacing-sm) var(--spacing-md);
    background: var(--bg-secondary);
    border: 2px solid transparent;
    border-radius: var(--radius-md);
    color: var(--text-secondary);
    font-size: 0.875rem;
    font-weight: 500;
    cursor: pointer;
    transition: all var(--transition-fast);
}

.effect-btn:hover {
    color: var(--text-primary);
    background: var(--bg-tertiary);
}

.effect-btn.active {
    color: var(--text-primary);
    border-color: var(--accent-cyan);
    background: rgba(34, 211, 238, 0.1);
}

.effect-btn-positive.active {
    border-color: #22c55e;
    background: rgba(34, 197, 94, 0.1);
    color: #22c55e;
}

.effect-btn-negative.active {
    border-color: #ef4444;
    background: rgba(239, 68, 68, 0.1);
    color: #ef4444;
}

.effect-btn-neutral.active {
    border-color: #94a3b8;
    background: rgba(100, 116, 139, 0.1);
    color: #94a3b8;
}

.effect-icon {
    font-size: 1rem;
}

.effect-text {
    font-weight: 600;
}

/* Category Tabs */
.category-tabs {
    display: flex;
    flex-wrap: wrap;
    gap: var(--spacing-sm);
    margin-bottom: var(--spacing-xl);
    padding: var(--spacing-sm);
    background: var(--bg-secondary);
    border-radius: var(--radius-lg);
}

.tab-btn {
    display: flex;
    align-items: center;
    gap: var(--spacing-xs);
    padding: var(--spacing-sm) var(--spacing-md);
    background: transparent;
    border: 1px solid transparent;
    border-radius: var(--radius-md);
    color: var(--text-secondary);
    font-family: inherit;
    font-size: 0.875rem;
    font-weight: 500;
    cursor: pointer;
    transition: all var(--transition-fast);
    white-space: nowrap;
}

.tab-btn:hover {
    color: var(--text-primary);
    background: var(--bg-card);
}

.tab-btn.active {
    color: var(--accent-cyan);
    background: var(--bg-card);
    border-color: var(--accent-cyan);
    box-shadow: 0 0 10px var(--accent-cyan-glow);
}

.tab-icon {
    font-size: 1rem;
}

/* Results Grid */
.results-grid {
    display: grid;
    grid-template-columns: repeat(auto-fill, minmax(340px, 1fr));
    gap: var(--spacing-lg);
}

/* Result Card */
.result-card {
    background: var(--bg-card);
    border: 1px solid var(--border-color);
    border-radius: var(--radius-lg);
    padding: var(--spacing-lg);
    transition: all var(--transition-base);
    animation: card-appear 0.5s ease-out backwards;
}

@keyframes card-appear {
    from {
        opacity: 0;
        transform: translateY(20px);
    }
}

.result-card:hover {
    transform: translateY(-4px);
    border-color: var(--accent-purple);
    box-shadow: 0 20px 40px -20px rgba(139, 92, 246, 0.3);
}

.card-header {
    display: flex;
    justify-content: space-between;
    align-items: center;
    margin-bottom: var(--spacing-md);
}

.card-badge {
    font-size: 0.75rem;
    font-weight: 600;
    padding: var(--spacing-xs) var(--spacing-sm);
    border-radius: var(--radius-sm);
    text-transform: uppercase;
    letter-spacing: 0.05em;
}

/* Badge Colors */
.badge-interesting {
    background: rgba(139, 92, 246, 0.2);
    color: var(--accent-purple);
}

.badge-extreme_rare {
    background: rgba(236, 72, 153, 0.2);
    color: var(--accent-pink);
}

.badge-rare {
    background: rgba(245, 158, 11, 0.2);
    color: var(--accent-amber);
}

.badge-personality {
    background: rgba(59, 130, 246, 0.2);
    color: var(--accent-blue);
}

.badge-disease {
    background: rgba(239, 68, 68, 0.2);
    color: var(--accent-red);
}

.badge-food {
    background: rgba(34, 197, 94, 0.2);
    color: var(--accent-green);
}

.badge-fitness {
    background: rgba(6, 214, 160, 0.2);
    color: var(--accent-cyan);
}

.badge-cognitive {
    background: rgba(139, 92, 246, 0.2);
    color: var(--accent-purple);
}

.badge-lifestyle {
    background: rgba(245, 158, 11, 0.2);
    color: var(--accent-amber);
}

.badge-appearance {
    background: rgba(168, 85, 247, 0.2);
    color: #a855f7;
}

.badge-longevity {
    background: rgba(20, 184, 166, 0.2);
    color: #14b8a6;
}

.badge-immunity {
    background: rgba(34, 197, 94, 0.2);
    color: #22c55e;
}

.card-rsid {
    font-family: 'JetBrains Mono', monospace;
    font-size: 0.75rem;
    color: var(--text-muted);
}

/* Effect-based card styling */
.result-card.effect-positive {
    border-left: 4px solid #22c55e;
}

.result-card.effect-positive:hover {
    border-color: #22c55e;
    box-shadow: 0 20px 40px -20px rgba(34, 197, 94, 0.3);
}

.result-card.effect-negative {
    border-left: 4px solid #ef4444;
}

.result-card.effect-negative:hover {
    border-color: #ef4444;
    box-shadow: 0 20px 40px -20px rgba(239, 68, 68, 0.3);
}

.result-card.effect-neutral {
    border-left: 4px solid #64748b;
}

.result-card.effect-neutral:hover {
    border-color: var(--accent-purple);
    box-shadow: 0 20px 40px -20px rgba(139, 92, 246, 0.3);
}

/* Effect indicator styling */
.effect-indicator {
    display: inline-flex;
    align-items: center;
    gap: 0.25rem;
    padding: 0.25rem 0.5rem;
    border-radius: var(--radius-sm);
    font-size: 0.75rem;
    font-weight: 600;
}

.effect-indicator.effect-positive {
    background: rgba(34, 197, 94, 0.15);
    color: #22c55e;
}

.effect-indicator.effect-negative {
    background: rgba(239, 68, 68, 0.15);
    color: #ef4444;
}

.effect-indicator.effect-neutral {
    background: rgba(100, 116, 139, 0.15);
    color: #94a3b8;
}

.card-title {
    font-size: 1.125rem;
    font-weight: 600;
    color: var(--text-primary);
    margin-bottom: var(--spacing-sm);
    line-height: 1.4;
}

.card-description {
    font-size: 0.875rem;
    color: var(--text-secondary);
    margin-bottom: var(--spacing-md);
    line-height: 1.6;
}

.card-genotype {
    display: flex;
    align-items: center;
    gap: var(--spacing-sm);
    padding: var(--spacing-md);
    background: var(--bg-secondary);
    border-radius: var(--radius-md);
    margin-bottom: var(--spacing-md);
}

.genotype-label {
    font-size: 0.75rem;
    color: var(--text-muted);
    text-transform: uppercase;
    letter-spacing: 0.05em;
}

.genotype-value {
    font-family: 'JetBrains Mono', monospace;
    font-size: 1.25rem;
    font-weight: 600;
    color: var(--accent-cyan);
    letter-spacing: 0.1em;
}

.card-details {
    display: flex;
    flex-direction: column;
    gap: var(--spacing-sm);
}

.detail-row {
    display: flex;
    justify-content: space-between;
    font-size: 0.8125rem;
}

.detail-label {
    color: var(--text-muted);
}

.detail-value {
    color: var(--text-secondary);
    font-weight: 500;
    text-align: right;
}

/* Empty State */
.empty-state {
    text-align: center;
    padding: var(--spacing-2xl);
    color: var(--text-muted);
}

.empty-state svg {
    width: 64px;
    height: 64px;
    margin-bottom: var(--spacing-lg);
    opacity: 0.5;
}

.empty-state h3 {
    font-size: 1.25rem;
    font-weight: 600;
    color: var(--text-secondary);
    margin-bottom: var(--spacing-sm);
}

/* ================================================
   Disclaimer
   ================================================ */

.disclaimer {
    margin-top: auto;
    padding-top: var(--spacing-xl);
    animation: fade-in 0.6s ease-out 0.4s backwards;
}

.disclaimer-content {
    display: flex;
    align-items: flex-start;
    gap: var(--spacing-md);
    padding: var(--spacing-lg);
    background: rgba(239, 68, 68, 0.1);
    border: 1px solid rgba(239, 68, 68, 0.2);
    border-radius: var(--radius-md);
    font-size: 0.875rem;
    color: var(--text-secondary);
    line-height: 1.6;
}

.disclaimer-content svg {
    width: 24px;
    height: 24px;
    color: var(--accent-red);
    flex-shrink: 0;
    margin-top: 2px;
}

.disclaimer-content strong {
    color: var(--accent-red);
}

/* ================================================
   Animations
   ================================================ */

@keyframes fade-in {
    from { opacity: 0; }
}

@keyframes fade-in-up {
    from {
        opacity: 0;
        transform: translateY(20px);
    }
}

@keyframes fade-in-down {
    from {
        opacity: 0;
        transform: translateY(-20px);
    }
}

/* ================================================
   Responsive Design
   ================================================ */

@media (max-width: 768px) {
    .container {
        padding: var(--spacing-md);
    }
    
    .logo h1 {
        font-size: 2rem;
    }
    
    .dna-icon {
        width: 40px;
        height: 40px;
    }
    
    .stats-overview {
        grid-template-columns: repeat(3, 1fr);
    }
    
    .category-tabs {
        justify-content: center;
    }
    
    .tab-text {
        display: none;
    }
    
    .tab-icon {
        font-size: 1.25rem;
    }
    
    .results-grid {
        grid-template-columns: 1fr;
    }
    
    .upload-area {
        padding: var(--spacing-xl);
    }
}

@media (max-width: 480px) {
    .logo h1 {
        font-size: 1.75rem;
    }
    
    .stat-value {
        font-size: 1.5rem;
    }
    
    .privacy-notice {
        flex-direction: column;
        text-align: center;
    }
}

/* ================================================
   DNA Helix Visualization Section
   ================================================ */

.dna-helix-section {
    background: var(--bg-card);
    border: 1px solid var(--border-color);
    border-radius: var(--radius-xl);
    padding: var(--spacing-xl);
    margin-bottom: var(--spacing-xl);
    overflow: hidden;
    position: relative;
}

.dna-helix-section::before {
    content: '';
    position: absolute;
    inset: 0;
    background: radial-gradient(ellipse at center, var(--accent-cyan-glow) 0%, transparent 60%);
    opacity: 0.1;
    pointer-events: none;
}

.helix-header {
    text-align: center;
    margin-bottom: var(--spacing-lg);
    position: relative;
    z-index: 1;
}

.helix-header h3 {
    font-size: 1.25rem;
    font-weight: 600;
    background: linear-gradient(135deg, var(--accent-cyan), var(--accent-purple));
    -webkit-background-clip: text;
    -webkit-text-fill-color: transparent;
    background-clip: text;
    margin-bottom: var(--spacing-xs);
}

.helix-header p {
    font-size: 0.875rem;
    color: var(--text-muted);
}

.dna-helix-container {
    position: relative;
    border-radius: var(--radius-lg);
    overflow: hidden;
    background: linear-gradient(135deg, rgba(10, 14, 23, 0.9), rgba(17, 24, 39, 0.95));
    border: 1px solid rgba(139, 92, 246, 0.2);
}

#dna-helix-canvas {
    width: 100%;
    height: auto;
    display: block;
}

.helix-controls {
    position: absolute;
    bottom: var(--spacing-md);
    left: 50%;
    transform: translateX(-50%);
    display: flex;
    align-items: center;
    gap: var(--spacing-md);
    padding: var(--spacing-sm) var(--spacing-md);
    background: rgba(17, 24, 39, 0.9);
    backdrop-filter: blur(10px);
    border-radius: var(--radius-lg);
    border: 1px solid var(--border-color);
}

.helix-btn {
    width: 36px;
    height: 36px;
    border-radius: 50%;
    border: none;
    background: linear-gradient(135deg, var(--accent-cyan), var(--accent-purple));
    color: white;
    cursor: pointer;
    display: flex;
    align-items: center;
    justify-content: center;
    transition: all var(--transition-fast);
}

.helix-btn:hover {
    transform: scale(1.1);
    box-shadow: 0 0 20px var(--accent-cyan-glow);
}

.helix-btn svg {
    width: 18px;
    height: 18px;
}

.speed-slider {
    width: 80px;
    height: 4px;
    -webkit-appearance: none;
    appearance: none;
    background: var(--bg-secondary);
    border-radius: 2px;
    outline: none;
}

.speed-slider::-webkit-slider-thumb {
    -webkit-appearance: none;
    width: 14px;
    height: 14px;
    border-radius: 50%;
    background: var(--accent-cyan);
    cursor: pointer;
    transition: all var(--transition-fast);
}

.speed-slider::-webkit-slider-thumb:hover {
    transform: scale(1.2);
    box-shadow: 0 0 10px var(--accent-cyan-glow);
}

.speed-label {
    font-size: 0.75rem;
    color: var(--text-muted);
    font-family: 'JetBrains Mono', monospace;
    white-space: nowrap;
}

.speed-label span {
    color: var(--accent-cyan);
}

/* Nucleotide Legend */
.nucleotide-legend {
    display: flex;
    justify-content: center;
    flex-wrap: wrap;
    gap: var(--spacing-lg);
    margin-top: var(--spacing-lg);
    padding: var(--spacing-md);
    background: var(--bg-secondary);
    border-radius: var(--radius-md);
}

.legend-item {
    display: flex;
    align-items: center;
    gap: var(--spacing-sm);
    font-size: 0.875rem;
    color: var(--text-secondary);
}

.legend-color {
    width: 16px;
    height: 16px;
    border-radius: 50%;
    box-shadow: 0 0 10px currentColor;
}

.legend-color.adenine {
    background: var(--color-adenine);
    color: var(--color-adenine);
}

.legend-color.thymine {
    background: var(--color-thymine);
    color: var(--color-thymine);
}

.legend-color.cytosine {
    background: var(--color-cytosine);
    color: var(--color-cytosine);
}

.legend-color.guanine {
    background: var(--color-guanine);
    color: var(--color-guanine);
}

/* DNA Stats Row */
.dna-stats-row {
    display: grid;
    grid-template-columns: repeat(4, 1fr);
    gap: var(--spacing-md);
    margin-top: var(--spacing-lg);
}

.dna-stat {
    text-align: center;
    padding: var(--spacing-md);
    background: var(--bg-secondary);
    border-radius: var(--radius-md);
    border: 1px solid var(--border-color);
    transition: all var(--transition-base);
}

.dna-stat:hover {
    transform: translateY(-2px);
    border-color: var(--accent-cyan);
}

.dna-stat:nth-child(1) .dna-stat-value { color: var(--color-adenine); }
.dna-stat:nth-child(2) .dna-stat-value { color: var(--color-thymine); }
.dna-stat:nth-child(3) .dna-stat-value { color: var(--color-cytosine); }
.dna-stat:nth-child(4) .dna-stat-value { color: var(--color-guanine); }

.dna-stat-value {
    display: block;
    font-size: 1.5rem;
    font-weight: 700;
    font-family: 'JetBrains Mono', monospace;
    margin-bottom: var(--spacing-xs);
}

.dna-stat-label {
    font-size: 0.75rem;
    color: var(--text-muted);
    text-transform: uppercase;
    letter-spacing: 0.05em;
}

/* Responsive adjustments for DNA Helix */
@media (max-width: 768px) {
    .dna-helix-container {
        margin: 0 calc(-1 * var(--spacing-md));
    }
    
    #dna-helix-canvas {
        height: 250px;
    }
    
    .helix-controls {
        flex-wrap: wrap;
        justify-content: center;
        bottom: var(--spacing-sm);
        padding: var(--spacing-xs) var(--spacing-sm);
    }
    
    .speed-slider {
        width: 60px;
    }
    
    .nucleotide-legend {
        gap: var(--spacing-md);
    }
    
    .legend-item {
        font-size: 0.75rem;
    }
    
    .dna-stats-row {
        grid-template-columns: repeat(2, 1fr);
    }
}

@media (max-width: 480px) {
    .dna-stats-row {
        grid-template-columns: repeat(2, 1fr);
    }
    
    .dna-stat-value {
        font-size: 1.25rem;
    }
}

/* ================================================
   PyScript Loading State
   ================================================ */

py-script {
    display: none;
}

/* Hide PyScript default styles */
.py-error {
    display: none !important;
}